Six-time champion Federer recorded his first loss when leading two sets to love. His record when winning the first two sets at Slams now stands at 178-1.
Jo-Wilfried Tsonga of France produced a stunning serving display in the last three sets of his quarterfinal with Federer to advance to his first Wimbledon semi.
Rafael Nadal erased any doubts about his form after a foot injury scare in his last match against Juan Martin del Potro. The defending champion won in four sets.
Bernard Tomic, just 18, hit more winners than the world No. 2 in their quarterfinal match. With the run, the Australian's ranking is expected to jump from No. 158 to somewhere in the 70s.
Andy Murray was the only player to advance in straight sets on Wednesday. He took out lefty Feliciano Lopez, 6-3, 6-4, 6-4.
